Founded with the mission to democratize access to precision weight loss medications, Alfie developed a virtual medical program based on top research from Cleveland Clinic and Harvard. The company offered personalized weight loss plans using AI to optimize exercise, nutrition, and medications. Alfie's multimodal approach aimed to be significantly more effective than standard prescription medications and habit-based methods, focusing on complex care pathways for obesity management.

Alfie was acquired by knownwell, a weight-inclusive primary care and metabolic health company. This acquisition led to the shutdown of standalone access to Alfie's platform and affiliated clinics. Alfie's notable achievements include creating a program that was twice as effective as standard medications and five times more effective than habit-based approaches. The merger with knownwell aims to further their shared mission of addressing unique health concerns without solely focusing on weight.