The Greisch Center for Enterprise Value is the named entrepreneurship hub of Creighton University, housed in the Heider College of Business and open to students from every school and college. It offers an entrepreneurship minor, intrapreneurship courses, applied certificates, and programs including Flight School, Flight Crew, and JayTank that help students test ideas and launch ventures.

The center connects students, faculty, alumni, and industry partners around venture creation, faculty commercialization, and entrepreneurial team-building. Signature activities include Founder Fridays, a one-day startup sprint, and a student-run entrepreneurship club that hosts weekly meetings and an annual pitch competition.