Violet Therapeutics is a preclinical-stage biotechnology company developing first-in-class therapies for neurodegenerative diseases by mapping disease-relevant cell-to-cell signaling interactions in the brain. The company's proprietary CONNECT platform enables discovery of novel targets emerging from cellular interaction networks rather than genetic association alone, supporting the development of a pipeline of small-molecule therapeutics addressing neuroinflammation and related CNS pathologies.
The company's lead program is a small molecule inhibitor of EphB3, a receptor tyrosine kinase that mediates microglia-astrocyte interactions driving glial dysfunction in neurodegenerative disease. Synaptic loss is one of the strongest predictors of cognitive decline in Alzheimer's disease and other neurodegenerative conditions, and Violet's lead program is designed to address this core pathology through glial-mediated synaptic preservation and repair.