Ameren Accelerator focuses on energy-related startups, particularly those innovating in energy grid technology, distributed generation, and digital communication. The program selects five to seven companies for a 12-week accelerator, providing $100,000 in funding, mentorship, office space, and additional resources. Typical investment rounds include seed, pre-seed, and convertible notes.

Notable portfolio companies include Shyft Power Solutions, Narya Security, and Omega Grid. The program is a collaboration between Ameren Corporation, a leading energy company, a top-10 accelerator, and a state university system. Ameren Accelerator emphasizes advancing traditional corporate accelerator models and offers unique value-add services such as extensive mentorship and strategic industry partnerships.