Centennial Investors focuses on providing early-stage capital to university and private sector entrepreneurs. The firm primarily invests in seed and Series A rounds, with occasional angel investments. Their portfolio spans various sectors, including biotechnology, agriculture, healthcare, and consumer products.

Notable portfolio companies include Plastomics, which has raised $7.1 million, and Endevica Bio and Mobility Designed, each raising $1.7 million. Centennial Investors aims to bring innovative ideas from university labs and private businesses to market, supporting the creation of new products, services, and jobs in their community.