Sphera Global Healthcare Fund, based in Tel Aviv, Israel, is a prominent fund management firm specializing in the healthcare sector. The firm primarily invests in Series B, Series C, and Series E rounds, as well as post-IPO equity, with a focus on both Israeli and U.S. markets. Sphera manages six distinct long/short equity strategies and one real estate private equity fund, leveraging a disciplined, fundamental investing approach overseen by a team of over twenty professionals.
Notable portfolio companies include aTyr Pharma, Deciphera Pharmaceuticals, Frontier Medicines, Immune-Onc Therapeutics, Outlook Therapeutics, and Werewolf Therapeutics. Sphera's investment philosophy emphasizes a repeatable process and deep sector expertise. The firm offers unique value-add services such as strategic guidance and operational support to its portfolio companies, ensuring they have the resources needed to succeed in the competitive healthcare landscape.
Sphera Global Healthcare Fund - Portfolio Snapshot
Portfolio activity breakdown across disclosed investments and stages
Top Investment Stages
Stage Mix

Sphera Global: A Tel Aviv-based fund management firm offering investment advice and portfolio services globally.
Concentration shown as share of disclosed investments by stage.

Sphera Funds Management
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Alive Israel Healthtech Fund
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Thyra Global Management
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Epiphron Capital

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Rapha Capital Management
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Spindletop Capital

Sarissa Capital Management
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Partner Fund Management

Ceiba Capital Management