TiE Boston is a venture capital firm and accelerator focusing on technology, life sciences, education, and clean technology sectors. The organization supports entrepreneurs through various programs, including TiE ScaleUp, which offers education, mentorship, networking, and funding opportunities. TiE Angels provides funding and advice to early-stage companies.

Notable portfolio companies include KnipBio, Sealonix, and Tagfi. TiE Boston's investment approach encompasses multiple stages, from seed to Series B rounds. The organization also runs TiE Young Entrepreneurs, a program designed to train high school students in entrepreneurship, demonstrating a commitment to fostering innovation across generations.