Daisy Genomics develops a physics-based sequencing platform that reads native DNA and RNA optically, pairing nanofluidic channels with plasmonic enhancement structures and surface-enhanced Raman spectroscopy instead of the chemical labeling, amplification, and enrichment that standard sequencing requires. The approach is designed to surface epigenetic modifications and sequence information that traditional methods cannot capture, feeding richer data into the machine-learning models precision medicine depends on.
Against amplification-based sequencing, its differentiation is mechanism and data depth, reading native molecules directly at single-base resolution and in real time instead of reconstructing short reads after days of library preparation. Daisy Genomics works with university research groups and diagnostics companies to build proof points in high-value applications such as liquid biopsy.