Boltz

Boltz-1 is the first fully commercially available open-source model to approach AlphaFold3-level accuracy in predicting 3D structures of proteins, RNA, DNA, and small molecules. Developed at MIT. MIT license.

Boltz-2 is a biomolecular foundation model that jointly predicts structure and binding affinity, going beyond AlphaFold3 and Boltz-1. Approaches FEP accuracy 1000x faster. Open source under MIT license.

BoltzGen is an all-atom generative diffusion model that designs proteins and peptides to bind arbitrary biomolecular targets. Unifies design and structure prediction. Experimentally validated with nanomolar binders on novel targets. MIT license.

Novartis screened nearly 350,000 compounds to find one starting point on Werner helicase. BoltzMol-1 found three functional hits from 27 compounds, for about $10,000.

Boltz Lab combines frontier AI models with intelligent agents for small-molecule hit discovery and de novo protein design. Built on Boltz-2 and BoltzGen. Scalable infrastructure, intuitive interfaces.

Boltz PBC was founded to advance AI in biology through open science, announcing Boltz Lab, a $28M seed round, and a partnership with Pfizer.

Boltz and Pfizer announce a strategic collaboration to develop and deploy biomolecular AI foundation models. Boltz will refine its models on Pfizer's extensive historical datasets to accelerate drug discovery.

Boltz and Bristol Myers Squibb announce an agreement to deploy the Boltz platform and co-develop custom biomolecular AI models for drug discovery.

Boltz partners with dsm-firmenich to apply its foundation models to ingredient discovery for scent and flavor molecules.

Boltz Lab offers 200 free predictions monthly, with pay-as-you-go pricing starting at $0.025 per prediction for small-molecule and protein design agents.

Foundational AI for Biology and Chemistry. Frontier models for designing all of life's molecules.

How Boltz PBC collects, uses, and protects information about individuals who use the Boltz Lab platform, APIs, models, website, and related services.

Browse Boltz legal documents: Boltz Lab Product Terms of Service, Privacy Notice, and the separate Website Terms that govern only boltz.bio.

Boltz Terms of Service governing access to and use of the Boltz software-as-a-service platform, APIs, AI models, and related technology.