constructive.bioCrawled Nov 6, 2026
The platform enables the development of ncAA therapeutics, including site-specific ADCs, engineered cytokines, covalent biologics, and oral peptides.
The 20 canonical amino acids provide limited side-chain shapes, which may not suit targets requiring precise geometric complementarity.
Constructive Bio enables new chemistry with non-canonical amino acid design that natural biology could never reach.
Constructive Bio enables proteins with non-canonical amino acids (ncAAs) for new-to-nature chemistries and next-generation therapies.
Beta-amino acids differ from the 20 standard amino acids by having an extra carbon in their backbone.
Most biologics function outside cells because proteins cannot naturally cross the plasma membrane.
BONCAT uses azidonorleucine (ANL) to label newly synthesized proteins in living cells.
Constructive Bio shares research, partnerships, and manufacturing advancements in non-canonical amino acid (ncAA) therapeutics.
Constructive Bio moved to new headquarters in the Cambridge Biomedical Cluster, occupying all lab space at Gen Two in Whittlesford.
Constructive Bio has been shortlisted for the One Nucleus Awards 2026 in the best use of emerging technology category.
Constructive Bio won the Life Science Scale-Up Award at the 35th Anniversary Business Weekly Awards in Cambridge.
The Financial Times covered Constructive Bio’s work in synthetic genomics and genetic code rewriting.
The Constructive Bio team includes Jason Chin and Nobel laureate Sir Gregory Winter, leaders in genetic code expansion.
Jason Chin, founder and CSO of Constructive Bio, received the SynBioBeta 2025 Impact Award for contributions to synthetic biology.
Constructive Bio appointed Fez Ujjainwalla as Chief Commercial Officer to advance its protein and peptide design platform.
Constructive Bio is an ncAA protein and peptide company that expanded the genetic code to manufacture therapeutics beyond natural biology.
Contact Constructive Bio to discuss therapeutics partnerships, investment, or general enquiries. Based in Cambridge, UK.
Constructive enables pharma partners to design and make ncAA protein and peptide therapeutics and biologic products.
Constructive Bio designs and manufactures new-to-nature chemistries for next-generation therapies and materials.
