The article evaluates mass spectrometry-based hydroxyl radical protein footprinting with a benchtop Flash Oxidation system against a synchrotron X-ray beamline.
Rohit Jain, Nayeon Jeon, Janna Kiselar, and Mark Chance are listed with Case Western Reserve University, School of Medicine, across three centers and departments.
The review discusses technologies for biopharmaceutical higher-order structural (HOS) analysis and the role of protein HOS in drug stability, safety, and biological function.
GenNext Technologies describes a workflow for protein structural analysis using the GenNext AutoFox Protein Footprinting System and Agilent 6560 Ion Mobility Quadrupole Time-of-Flight (IM-QTOF) LC/MS system.
The company’s Fox Radical Protein Footprinting Technology uses hydroxyl radicals to examine the solvent accessibility of protein amino acid side chains by selectively labeling exposed amino acids.