MindRhythm

MindRhythm®: A leading brain wellness company innovating in stroke prevention technology.

Founded

2019

Competitive Advantages

Harmony gives emergency responders an objective prehospital measurement where none existed, combining cranial accelerometry with a brief limb-weakness examination to resolve the triage question that symptom scales alone could not settle. The EPISODE program, spanning six states with seventeen hospitals and fourteen emergency-services agencies, is described as the largest evaluation of a prehospital stroke device, and its pilot publication showed higher sensitivity than a standard stroke scale without reduced specificity.

The device is designed for use by emergency professionals of any skill level, returns a simple yes-or-no output, and transmits data with location status to the receiving hospital. An FDA Breakthrough Device Designation, peer-reviewed publications in 2019, 2020, and 2024, and a founding team pairing a UCSF stroke neurologist, an inventor, and an experienced commercialization executive further distinguish the company in stroke triage.

Source: mindrhythm.com

Memo

MindRhythm is a Cupertino medical technology company founded in 2019 to prevent neurological injury from stroke by fixing prehospital triage. Its disposable Harmony headset measures the HeadPulse cranial signal and tells emergency responders within minutes whether a patient is suffering a large vessel occlusion, so severe strokes reach comprehensive stroke centers faster and other strokes reach primary stroke centers without delay.

The company completed enrollment in the multicenter EPISODE trial in late 2023, published pilot results in a peer-reviewed emergency medicine journal in 2024, and earned an FDA Breakthrough Device Designation. With a $5 million seed round funding the trial program and a concussion monitoring line extending the same physiology, MindRhythm is positioned as a pre-commercial neurodiagnostic company preparing for regulatory clearance.

Product Overview

MindRhythm offers the Harmony headset for prehospital identification of large vessel occlusion strokes and a HeadPulse-based service for concussion confirmation and recovery monitoring. Harmony is a disposable headband placed by emergency responders; its accelerometer records cranial pulsations from each heartbeat, and onboard software reports within minutes whether a severe stroke is present so patients can be routed to a capable hospital.

The HeadPulse service applies the same cranial measurement to concussion, giving clinicians an objective under-two-minute reading that confirms injury and can be repeated over time to track healing. Together the offerings address the lack of objective prehospital tools for stroke triage and the symptom-dependent nature of concussion diagnosis and return-to-activity decisions.