Nexus Medical

The Nexus TKO needleless connector uses anti-reflux technology to provide bidirectional flow control for IV catheters.

1 – Nexus TKO-6P Luer-Activated Anti-Reflux Device (non-bonded) 60” Ultra-Microbore Tubing [0.020” ID] Rotating male luer lock Blue non-removable slide clamp Approx. priming volume – 0.52 mL

Anti-reflux needleless connector with clear housing intended for use as an accessory to an IV Catheter for administration of blood, IV drugs and IV fluids including neonatal, pediatric and immunocompromised patients. Bonded 6″ high pressure microbore extension set with non-removable slide clamp and rotating male luer lock. Not made with DEHP. Not made with natural rubber latex. Priming volume: 0.40 mL. Power injection rated to 325 psi at 10 mL/sec. (Nexus Medical Cross: N4685MN-B)

The Infusion Nurses Society expanded its guidance on the use of needleless connectors to include anti-reflux technology in its 2021 Infusion Therapy Standards of Practice.

Lee Steere, RN, CRNI, VA-BC, describes how Hartford Hospital’s vascular access specialty team improved infusion therapy practices through a quality initiative.

Nancy Moureau and Lee Steere discuss how Nexus products helped health systems adapt to the pandemic by securing supplies and enhancing safety.

Nancy Moureau, RN, PhD, CEO of PICC Excellence, explains the proper use of needleless connectors and how INS Standards guide their selection.

Nexus Medical joined Avanos Medical in September 2025, combining expertise to improve patient care in critical and acute environments.

Nexus Medical, LLC began in 2000 when the U.S. Army Medical Material Command in Fort Detrick Maryland awarded a grant to research unintentional blood reflux into IV catheters and prevent the many unintended consequences it caused the Warfighters.

Nexus Medical’s engineers learned blood reflux was caused by a multiplicity of physiological (internal) and mechanical (external) pressure fluctuations in the patient’s closed IV system.

Nexus Medical’s engineers studied the human factors associated with internal and external pressures causing blood reflux into peripheral IV catheters, midlines, PICC and CV catheters.

Study demonstrates that TKO has the least amount of reflux compared to 14 commercially available needleless connectors (published in the Journal of Vascular Access)

Nexus Medical offers samples of its I.V. Therapy devices upon request.

Nexus TKO anti-reflux needleless connector is the latest advancement among CVAD & PICC line needleless devices. It contains a bidirectional, pressure-sensitive valve that prevents occlusions as compared to other IV needleless connectors.