OpenEvidence

OpenEvidence (Xyla Inc.) is an AI-powered clinical decision support platform that aggregates, synthesizes, and visualizes peer-reviewed medical research for healthcare professionals. Founded in 2021 and headquartered in Miami, Florida, the platform is used by over 760,000 registered physicians—representing more than 40% of U.S. doctors—to stay current with the latest clinical evidence and research literature. The company leverages artificial intelligence and machine learning to combat information overload in medicine and enhance patient care.

OpenEvidence is a Mayo Clinic Platform Accelerate Company and has partnered with Elsevier to launch ClinicalKey AI, integrating trusted content from prominent medical journals and resources. Notable affiliations include Ram Dandillaya of Cedars-Sinai, Antonio Forte of Mayo Clinic, John Lee of Harvard Medical School, and Nobel Laureate Daniel Kahneman. The company has raised approximately $735 million in total funding and was valued at $12 billion as of January 2026, with reported annual recurring revenue of $150 million as of December 2025.