Pumpkinseed Bio

deSIPHR’s reference-free proteomic data supports foundation models for biology, accelerates drug discovery, and enables next-generation biothreat detection.

deSIPHR generates reference-free, single cell and single molecule proteomic data at semiconductor scale - the training data foundation models for biology need.

Pumpkinseed Bio's nanophotonic platform is unlocking a new era in precision cancer immunotherapy — enabling label-free, AI-powered tumor profiling at the single-cell level.

Stanford and Pumpkinseed use single-cell Raman and ML to detect bacterial pathogens in wastewater. This proof-of-concept work establishes that Raman can be used to detect biothreats without amplification for wastewater-based epidemiology.

Pumpkinseed co-founders Jack Hu and Stanford Professor Jennifer Dionne introduced DynaSpec, a computational framework mapping molecular structure to Raman spectral signatures with over 85% accuracy across 13 glycan structures. This research supports deSIPHR’s ability to read complex biomolecules from vibrational fingerprints.

Pumpkinseed co-founders Nhat Vu and Jennifer Dionne demonstrate that single-cell Raman spectroscopy and AI can predict melanoma treatment resistance with 91% accuracy across patient-drug combinations.

Pumpkinseed shares updates, including press coverage, company announcements, and team insights on proteomics and biological AI.

Pumpkinseed raised $20 million in Series A funding, co-led by NfX and Future Ventures, to scale its deSIPHR nanophotonic chip platform for peptide and full-length protein sequencing, advancing biopharma, biosecurity, and proteomic datasets.

Stanford Professor Jennifer Dionne discusses how Pumpkinseed’s nanophotonic chip platform enables high-resolution, large-scale proteome investigation, impacting drug discovery, AI biology, and medicine.

Pumpkinseed originated at Stanford, where nanophotonics, biochemistry, and machine learning converged to address the challenge of making biology’s most important data layer readable. The team developed an instrument to achieve this.

Pumpkinseed seeks biopharma partners, collaborators, team members, and investors to explore pilot programs, collaborations, employment, or the platform. Contact via info@pumpkinseed.bio.

Pumpkinseed is The Biology Mining Company, extracting biology's most valuable data layer at a resolution and scale that was previously impossible. Its deSIPHR platform enables fully de novo sequencing, serving partners across bio-AI, biopharma, and biosecurity.

Pumpkinseed is The Biology Mining Company, extracting biology's most valuable data layer at a resolution and scale that was previously impossible. Its deSIPHR platform enables fully de novo sequencing, serving partners across bio-AI, biopharma, and biosecurity.