SonoThera is a biotechnology company developing ultrasound-mediated nonviral genetic medicines for diseases including Duchenne muscular dystrophy and hemophilia A.
SonoThera develops a proprietary nonviral gene delivery platform called RIPPLE that pairs intravenously injected microbubble ultrasound enhancing agents with externally applied therapeutic ultrasound to transport DNA and RNA payloads into targeted tissues. Preclinical programs target Duchenne muscular dystrophy, autosomal dominant polycystic kidney disease, X-linked Alport syndrome, and hemophilia A.
Headquartered in South San Francisco, SonoThera was founded in 2021 by Kenneth Greenberg, Steven Feinstein, and Michael Davidson and closed an oversubscribed $125 million Series B financing in June 2026 led by Vida Ventures. The company holds exclusive licenses for the Optison and Sonazoid microbubble products from GE HealthCare and plans to initiate its first clinical trial in Duchenne muscular dystrophy in 2027.