X-Chem

Ferenc Andreáni’s article discusses how DNA-encoded libraries (DEL) have become a widely used method for identifying drug discovery hits over the past 20 years.

At X-Chem, computational sciences are embedded at the core of drug discovery, translating complex datasets into clear, design-ready insights.

Our DNA-encoded library (DEL) technology is a powerful tool to catalyze the industry’s identification of novel covalent small molecules.

X-Chem integrates medicinal and synthetic chemistry teams with screening and computational chemistry to advance drug discovery programs.

Anthony D. Keefe, Ph.D., notes that covalent drugs such as aspirin and penicillin form permanent bonds with targets, enhancing potency.

Matt Clark, Ph.D., describes how DNA-encoded library screens often yield long lists of peptides and peptidomimetics.

Shawn Johnstone explains that protease-activated receptor-2 ligands reveal orthosteric and allosteric inhibition mechanisms in GPCRs.

X-Chem engages with advances in DNA-encoded library technology to support drug discovery applications, including frontline screening and innovative uses.

Matt Clark highlights X-Chem’s commitment to solving client problems and creating scientific value.

By Zhen Chen, Senior Principal Scientist Solving the biggest challenge in RNA-targeted DEL screens with a mirror-image approach. RNA-targeted [...]

The page provides an archive of X-Chem’s press releases spanning over 10 years, covering new technologies and partnerships.

CandidateBuilder is X-Chem’s most advanced engagement model. A solution for teams seeking a path from validated hit to IND-ready candidate.

X-Chem has pioneered DNA-encoded chemical library technology since 2009 and continues to innovate.

X-Chem’s Fee for Service model provides access to its platform, expertise, and technologies tailored to client goals.

Karen Lackey brings over 30 years of drug discovery leadership to X-Chem, with experience in academia and biotech roles.

Matthew A. Clark leads X-Chem as President and Chief Scientific Officer, driving innovation in DNA-encoded library technology.

Meet Our Scientific Advisory Board Our Scientific Advisory Board is made up of experienced discovery leaders who have advanced programs from concept to clinic across pharma, biotech, and academia. They provide critical insight to ensure we connect data, design, and chemistry in ways that move discovery forward with clarity and confidence. Hans-Joachim

X-Chem’s DEL platform enables rapid screening of billions of drug-like compounds against targets, leveraging diverse chemical libraries.

X-Chem combines scientific rigor, strategic flexibility, and data-driven insights for chemomics in drug discovery.

X-Chem pioneers DNA-encoded library science and advances drug discovery methods.

Our difference is, we do more than screen compounds. We help you make confident decisions that move science forward.