Illumina Ventures focuses on early-stage investments in genomics and life sciences companies. The firm typically invests in Series A and B rounds, with a strong presence in later stages as well. Their portfolio spans a wide range of genomics applications, including therapeutics, diagnostics, and research tools.

Notable portfolio companies include 23andMe, Twist Bioscience, and Delfi Diagnostics. Illumina Ventures aims to improve human health by unlocking the power of the genome, offering strategic guidance and industry expertise to their portfolio companies. The firm's investments reflect a commitment to advancing genomic technologies and their applications in healthcare and biotechnology.