Open Access Ventures applies a private equity approach to seed-stage investments, focusing on startups with highly talented founders who possess strong domain expertise and industry influence. The firm typically invests in pre-seed rounds, providing capital, talent, and advisory resources to support early-stage entrepreneurs.

The firm's portfolio includes companies like Growth3 and Mverse.Audio. Open Access Ventures seeks founders with proven track records and the dedication necessary to become industry leaders. Their investment thesis emphasizes backing entrepreneurs who have gained access to essential resources for success, aligning with the firm's goal of bringing a private equity approach to seed-stage investing.