White Buffalo Capital is a venture capital firm based in New York and Jackson Hole, focusing on early-stage investments in natural sciences, media, and alternative energy sectors. The firm typically invests in seed to Series B rounds, with occasional participation in later stages like Series D.

Notable portfolio companies include Momentus (MNTS), Vaxxinity (VAXX), Heliogen (HLGN), Fnatic, Mend, Geltor, Ripple Foods, Halo Industries, BlueNalu, Upward Farms, Medly Pharmacy, and Motif FoodWorks. White Buffalo Capital's investment philosophy centers on discovering innovative companies at the intersection of traditional and emerging industries, as reflected in their motto "Find us on the old frontier, discovering the new."